- Discovery of the Americas: Christopher Columbus's arrival in the Americas on October 12, 1492, happened on a Monday.
- Apollo 11 Moon Landing: Neil Armstrong and Buzz Aldrin's historic moonwalk on July 20, 1969, occurred on a Monday.
- First Successful Vaccine: Edward Jenner administered the first successful smallpox vaccine on May 14, 1796, which was a Monday.
- First Successful Heart Transplant: Dr. Christiaan Barnard performed the world's first successful heart transplant on December 3, 1967, which was a Monday.